Grounded in research, with real results.

• Pain management: Of the participants receiving the app-based GDH 71% had a clinically significant decrease in abdominal pain compared to 35% receiving the active control.
• Symptom severity: Of the participants receiving the app-based GDH, 81% had an improvement (≥50 points) in IBS Symptom Severity Scale (IBS-SSS) scores compared to 63% receiving the active control.
• Quality of life and mental health: Of the participants receiving app-based GDH, 28% reported an increase in quality of life and a 37.5% decrease in anxiety.

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Nerva by Mindset Health‍

This report is based on a cross-sectional survey completed by 3,403 respondents. Despite IBS being one of the most commonly diagnosed GI disorders, respondents reported facing a fragmented and frustrating path to care.

• The 2025 ESPGHAN/NASPGHAN guidelines recommend gut-directed hypnotherapy as a first-line treatment for children with IBS and FAP-NOS.
• Hypnotherapy showed the strongest evidence and greatest effect among all therapies reviewed.
• Both provider-delivered and home-based programs are effective, offering flexibility for families and clinicians.

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Completion of gut-directed hypnotherapy via an app-delivered program appears to have a response rate similar to that reported for face-to-face therapy without apparent adverse effects.

• Nerva, significantly improves gastrointestinal symptom management and psychological outcomes in the majority of pediatric patients.
• It is particularly effective in improving outcomes for those with moderate and severe levels of anxiety and/or depression.
• These findings support the use of Nerva in pediatric populations and suggest the need for further research.

• This perspective paper determined that clinical hypnosis demonstrates significant efficacy in managing health concerns, as evidenced by recent randomized control trials and meta-analyses.
• Advances in scientific rigor have established clinical hypnosis as a credible intervention, though its application remains underutilized.
• Emerging hypnotherapy apps integrate evidence-based techniques, offering scalable and cost-effective solutions to diverse patient populations.

• App-delivered gut-directed hypnotherapy improves overall and individual gastrointestinal symptoms.
• Users who complete the program report greater improvement in psychological outcomes.
• Healthcare practitioner referral is a positive predictor of program completion, but it does not alter rates of efficacy.

• Money spent on managing IBS symptoms reduced significantly for Nerva app users after the 6 week program and remained stable at 6-months.
• Nerva users reported significant long-term improvements in absenteeism, presenteeism, work productivity loss and impairment in preforming daily activities post program completion.

• The characteristics of the Nerva app users largely mirror previously documented demographic and clinical characteristics of individuals with IBS in the wider literature.
• Study found promising adherence rates for the Nerva app program within the six program.

• Mobile app-delivered gut-directed hypnotherapy significantly improved overall and specific symptoms of IBS similar to rates seen in face-to-face trials.
• IBS patients who respond poorly to medications may respond better.
• Mobile app-delivered gut-directed hypnotherapy may provide a cost-effective and accessible alternative to otherwise expensive treatment and enable the widespread use of the treatment, despite limited numbers of trained professionals.

• Durable effects of gut-directed hypnotherapy are similar to those of the low FODMAP diet for relief of gastrointestinal symptoms.
• Hypnotherapy has superior efficacy to the diet on psychological indices.