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Grounded in research, designed for results.

Nerva’s protocol is built on research, including RTCs from world-leading institutions. Explore the clinical trials, peer-reviewed publications, and guidelines that support Nerva’s gut-brain therapy for DGBIs.
Research
Guidelines

Clinically backed real-world outcomes

9
Research
publications
100k+
Participants contributing to published evidence
81%
Achieved clinically significant improvement 1

Research studies

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Annual Report
The State of IBS 2025 Report

Nerva by Mindset Health‍

This report is based on a cross-sectional survey completed by 3,403 respondents. Despite IBS being one of the most commonly diagnosed GI disorders, respondents reported facing a fragmented and frustrating path to care.

The State of IBS 2025 Report

Ongoing research

Functional Gut Symptoms in Quiescent IBD and IBS

Clinical trial evaluating whether app-based gut-directed hypnotherapy can reduce functional gut symptoms in IBD patients in remission who still experience IBS-like symptoms.

Evaluation of the Nerva program for UGI

Exploring Nerva's effectiveness in managing upper-GI symptoms.

Evaluation of the Nerva Program for Pediatric Populations

Understanding the acceptability and outcomes for children and adolescents with IBS.

Retention in 65+

Understanding patterns of usage and outcomes for older adults using Nerva.

Clinical Guidelines

Gut-brain therapy is recommended as a highlighted by every major gastroenterology guideline body

American College of Gastroenterology

"Recognition of the brain–gut axis and performance or referral for brain–gut behavior therapies, such as cognitive behavioral therapy or gut-directed hypnotherapy."
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ESPGHAN/NASPGHAN

European/North American Paediatric Guidelines 2025) - European/North American Paediatric Guidelines
"Data synthesis of hypnotherapy trial results had the highest GRADE certainty level of evidence among all treatment options reviewed for these guidelines."
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American Gastroenterological Association

"Highlighting the use of brain-gut behavior therapies as a quality indicator will encourage expanded utilisation and access of this evidence-based, effective therapy."
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Learn more

The Rome FoundationMedical Journal of AustraliaNational Institute for Health and Care ExcellenceCanadian Association of Gastroenterology (CAG) IBS GuidelineHealthify NZ Gov IBS Treatment GuidelinesBritish Society of Gastroenterology (BSG) GuidelineUEG/ESNM European Guideline
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*Disclaimer: Nerva is a self-guided program that may help people self-manage and live well with their diagnosed disorder of the gut-brain interaction. Nerva has not been evaluated by the FDA, TGA, MHRA or equivalent regulatory bodies. Users are directed not to make any changes to their prescribed medication or other type of medical treatment without seeking professional medical advice. Some in-app coaching content may be generated by an AI system for educational and wellness purposes only and does not replace professional medical care, diagnosis, or treatment.
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